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Which step is NOT involved in the process of rabies infection in humans?

  1. Virus replicates in muscle near the bite

  2. Virus enters the bloodstream

  3. Virus moves up the Nervous System

  4. Virus reaches the brain causing fatal encephalitis

The correct answer is: Virus enters the bloodstream

The process of rabies infection typically follows a well-defined sequence. Initially, the rabies virus enters the body usually through a bite from an infected animal. Once introduced, the virus replicates in the muscle cells surrounding the site of the bite. This replication stage is critical for the virus to establish a foothold in the host. After replication occurs, the virus then moves along the peripheral nervous system, utilizing the neural pathways to travel swiftly toward the central nervous system. This is a vital aspect of the infection process, as the virus is highly specialized for neurological invasion. When it reaches the brain, the rabies virus can cause severe neurological damage, leading to symptoms such as confusion, agitation, and ultimately, fatal encephalitis. The step involving entry into the bloodstream, however, is not part of the rabies infection process in humans. Unlike many viruses that spread through the bloodstream to various organs, the rabies virus predominantly travels via the nervous system. This characteristic helps explain the virus's mode of transmission and its effects on the central nervous system, which ultimately leads to its severe and often fatal consequences. Thus, recognizing that the rabies virus does not utilize the bloodstream for its transport is key in understanding the progression of the disease.